Design of orally active, non-peptidic inhibitors of human leukocyte elastase

J Med Chem. 1994 Apr 29;37(9):1259-61. doi: 10.1021/jm00035a004.

Authors

F J Brown¹, D W Andisik, P R Bernstein, C B Bryant, C Ceccarelli, J R Damewood Jr, P D Edwards, R A Earley, S Feeney, R C Green, et al.

Affiliation

¹ Department of Medicinal Chemistry, ZENECA Pharmaceuticals Group, Wilmington, Delaware 19897.

PMID: 8176703
DOI: 10.1021/jm00035a004

No abstract available

MeSH terms

Amino Acid Sequence
Animals
Binding Sites
Biological Availability
Cricetinae
Drug Design*
Humans
Leukocyte Elastase
Molecular Sequence Data
Molecular Structure
Oligopeptides / chemistry
Pancreatic Elastase / antagonists & inhibitors*
Pyrimidinones / chemical synthesis*
Pyrimidinones / pharmacokinetics
Pyrimidinones / pharmacology
Rats

Substances

Oligopeptides
Pyrimidinones
ICI 200880
2-(4-fluorophenyl)-5-((methoxycarbonyl)amino)pyrimidin-4-one-3-ethanoylvaline-trifluoromethylketone
Pancreatic Elastase
Leukocyte Elastase